Functions and biosynthesis of plasmalogens in health and disease

Biochim Biophys Acta. 2004 Mar 22;1636(2-3):219-31. doi: 10.1016/j.bbalip.2003.12.010.


Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Hydrolysis
  • Plasmalogens / biosynthesis*
  • Plasmalogens / metabolism
  • Plasmalogens / physiology*
  • Subcellular Fractions / metabolism


  • Plasmalogens