Adenovirus Types 5 and 35 Seroprevalence in AIDS Risk Groups Supports Type 35 as a Vaccine Vector

AIDS. 2004 May 21;18(8):1213-6. doi: 10.1097/00002030-200405210-00019.

Abstract

The seroprevalence of adenovirus types 5 (Ad5) and 35 (Ad35) was investigated in patients at risk of AIDS. The seroprevalence of Ad5 was higher than Ad35 in HIV-infected patients from The Netherlands (60% versus 7%) and sub-Saharan Africa (90% versus 20%). The seroprevalence was similar among HIV-infected and uninfected individuals, and remained constant during progression to AIDS. Ad35 is less prone to neutralization than Ad5, encouraging the further development of Ad35 for vaccination against HIV.

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology*
  • Adenoviruses, Human / immunology
  • Adenoviruses, Human / isolation & purification*
  • Africa South of the Sahara / epidemiology
  • Antibodies, Viral / blood*
  • Genetic Vectors
  • Humans
  • Netherlands / epidemiology
  • Risk Factors
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral