Effect of topical bupivacaine on postoperative pain after laparoscopic tubal sterilization with Filshie clips

Am J Obstet Gynecol. 2004 May;190(5):1411-3. doi: 10.1016/j.ajog.2004.01.068.


Objective: The purpose of this study was to evaluate postoperative pain after the administration of topical bupivacaine during laparoscopic sterilization with Filshie clips.

Study design: Sixty-three women who underwent laparoscopic tubal sterilization with Filshie clips were assigned randomly to receive topical bupivacaine or placebo. Presence of pain, pain intensity, nausea, vomiting, timing of request for pain medication, and pain medication requirements were assessed postoperatively.

Results: Patient demographics were similar between the 2 groups. Topical bupivacaine decreased the incidence (P=.005) and intensity (P=.028) of postoperative pain at 30 minutes. No differences in incidence or severity of pain were seen at hospital discharge or on postoperative day 1.

Conclusion: Topical bupivacaine that is applied to the fallopian tubes at the time of laparoscopic tubal sterilization with the Filshie clip decreases immediate postoperative pain.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Bupivacaine / administration & dosage*
  • Female
  • Humans
  • Laparoscopy / adverse effects
  • Laparoscopy / methods*
  • Middle Aged
  • Pain Measurement
  • Pain, Postoperative / diagnosis*
  • Pain, Postoperative / drug therapy*
  • Probability
  • Reference Values
  • Severity of Illness Index
  • Sterilization, Tubal / adverse effects
  • Sterilization, Tubal / instrumentation*
  • Treatment Outcome


  • Bupivacaine