The ideal lavage volume for removing bradykinin, interleukin-6, and protein from the temporomandibular joint by arthrocentesis

J Oral Maxillofac Surg. 2004 Jun;62(6):657-61. doi: 10.1016/j.joms.2003.08.031.


Purpose: The aim of this study was to investigate the ideal volume of perfusate for arthrocentesis of the temporomandibular joint (TMJ) disorders (TMDs).

Patients and methods: We evaluated 17 joints in 17 patients with TMD in this study. Arthrocentesis of the TMJ was done by perfusion of 400 mL of Ringer's solution. The first 5 mL of perfusate was collected, and then a 5-mL sample was collected when the total volume of perfusate outflow approached 50, 100, 200, 300, and 400 mL. The concentrations of bradykinin, interleukin-6, and protein were measured by immunoassay.

Results: The concentration of bradykinin, interleukin-6, and protein during arthrocentesis were effectively reduced by more than 200 mL of lavage (P <.05). With a perfusate volume of 300 to 400 mL, the protein and bradykinin were no longer detectable.

Conclusions: Arthrocentesis is effective for washing out bradykinin, interleukin-6, and protein from the TMJ, and the ideal lavage volume of perfusate for arthrocentesis is between 300 and 400 mL.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bradykinin / metabolism*
  • Female
  • Humans
  • Inflammation Mediators / metabolism
  • Interleukin-6 / metabolism*
  • Male
  • Middle Aged
  • Pain / etiology
  • Pain / metabolism*
  • Paracentesis / methods*
  • Proteins / metabolism
  • Synovial Fluid / metabolism
  • Temporomandibular Joint Disorders / complications
  • Temporomandibular Joint Disorders / metabolism
  • Temporomandibular Joint Disorders / therapy*
  • Therapeutic Irrigation / methods*
  • Treatment Outcome


  • Inflammation Mediators
  • Interleukin-6
  • Proteins
  • Bradykinin