Effect of haemodialysis on the pharmacokinetics of antineoplastic drugs

Clin Pharmacokinet. 2004;43(8):515-27. doi: 10.2165/00003088-200443080-00002.

Abstract

Since renal failure itself creates an immunocompromised situation, malignant tumours in haemodialysis patients are increasing due to the prolonged lifespan of these patients. In treating these patients with anticancer agents, dosage reduction is often recommended to avoid adverse drug reactions, particularly for drugs with extensive renal excretion. On the other hand, if an anticancer drug is removed significantly by haemodialysis, dosage increase would be required to ensure adequate therapeutic efficacy. We address in this review the clinical pharmacokinetic aspects of antineoplastic therapy, and the application of pharmacokinetic principles to the adjustment of dosage of anticancer agents in haemodialysis patients.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / therapeutic use
  • Area Under Curve
  • Female
  • Half-Life
  • Humans
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / metabolism
  • Kidney Failure, Chronic / therapy
  • Male
  • Metabolic Clearance Rate
  • Neoplasms / complications
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Renal Dialysis*

Substances

  • Antineoplastic Agents