PI-loting membrane traffic

Nat Cell Biol. 2004 Jun;6(6):487-92. doi: 10.1038/ncb0604-487.


Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action is not always well defined, but it includes localized recruitment of transport machinery, allosteric regulation of PI-binding proteins and changes in the physical properties of the membrane.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Compartmentation / physiology*
  • Humans
  • Intracellular Membranes / metabolism*
  • Intracellular Membranes / ultrastructure
  • Membrane Fusion / physiology
  • Organelles / metabolism*
  • Organelles / ultrastructure
  • Phosphatidylinositols / metabolism*
  • Protein Transport / physiology*
  • Signal Transduction / physiology
  • Transport Vesicles / metabolism
  • Transport Vesicles / ultrastructure


  • Phosphatidylinositols