Background: Microcystic adnexal carcinoma is a clinically aggressive, local destructive sweat gland carcinoma with a high rate of recurrence, but regional or distant metastasis is quite rare.
Objective: The objective was to describe an autopsy case of microcystic adnexal carcinoma with hematogenous metastasis and perineural intracranial spreads.
Methods: This is an autopsy case of a 73-year-old woman with hematogenous metastasis of microcystic adnexal carcinoma followed for more than 20 years.
Result: The autopsy study revealed that the metastatic lesions were located in the perineural intracranial spread, left clavicle bone, bilateral 12th ribs, and liver.
Conclusion: Physicians should be aware that microcystic adnexal carcinoma is capable of metastasis to the liver and bones with intracranial spread along the optic nerve into the cranium.