Consideration of the risk and treatment of tuberculosis in patients who have rheumatoid arthritis and receive biologic treatments

Rheum Dis Clin North Am. 2004 May;30(2):257-70, v. doi: 10.1016/j.rdc.2004.01.003.


Evidence supports the association of tuberculosis (TB) with tumor necrosis factor inhibitor therapy in patients who have rheumatoid arthritis. There seem to be differential risks of TB with the currently available inhibitors. Screening for latent TB infection with purified protein derivative is indicated for patients who are being considered for treatment; it seems to be effective in reducing the occurrence of TB in treated patients.

Publication types

  • Review

MeSH terms

  • Antirheumatic Agents / adverse effects*
  • Antitubercular Agents / therapeutic use
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / immunology
  • Biological Therapy / adverse effects*
  • Humans
  • Risk
  • Tuberculosis / drug therapy*
  • Tuberculosis / etiology
  • Tuberculosis / immunology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / immunology


  • Antirheumatic Agents
  • Antitubercular Agents
  • Tumor Necrosis Factor-alpha