Prolongation of T(2) relaxation times of hippocampus and amygdala in Alzheimer's disease

Neurosci Lett. 2004 Jun 10;363(2):150-3. doi: 10.1016/j.neulet.2004.03.061.


There exists controversy on the MR T(2) relaxometry of hippocampus in Alzheimer's disease (AD). The aim of our study was to examine whether there was a prolonged T(2) relaxation time (T(2)) in hippocampus and amygdala in AD, and whether in AD, the relaxometry data correlated to cognitive performance. In a 1.5 T MR scanner, T(2) of hippocampus and amygdala was measured from 51 patients with AD, 23 subjects with vascular dementia (VaD) and 31 healthy elderly controls. The cognitive performance was assessed with the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog). The AD patients had longer T(2) in hippocampus and amygdala than VaD subjects and healthy elderly controls. In AD, the right hippocampal T(2) was correlated with ADAS-Cog scores, whereas amygdaloid T(2) was not.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / physiopathology
  • Amygdala / metabolism
  • Amygdala / pathology*
  • Amygdala / physiopathology
  • Body Water / metabolism
  • Cognition / physiology
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / physiopathology
  • Dementia, Vascular / diagnosis*
  • Dementia, Vascular / physiopathology
  • Female
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Hippocampus / physiopathology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Reference Values
  • Reproducibility of Results
  • Severity of Illness Index