A complex rearrangement of chromosome 7 in human astrocytoma

Cancer Genet Cytogenet. 2004 Jun;151(2):162-70. doi: 10.1016/j.cancergencyto.2003.09.017.


Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Astrocytoma / genetics*
  • Brain Neoplasms / genetics*
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 7*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping