Association of rheumatologic disease with preeclampsia

Obstet Gynecol. 2004 Jun;103(6):1190-3. doi: 10.1097/01.AOG.0000126279.87151.e1.


Objective: To determine whether maternal rheumatologic disease is associated with an increased risk of adverse obstetric or neonatal outcomes.

Methods: Using an institutional database, we identified all women with diagnosed rheumatologic disease (n = 114) who delivered a baby at our institution during a 33-month period. We compared the incidence of adverse obstetric and neonatal outcomes among these women with the incidence among women without rheumatologic diseases (n = 18,534).

Results: Women with rheumatologic diseases were more likely to have preeclampsia than women without rheumatologic disease (8.8% versus 2.3%, P <.001) Women with rheumatologic diseases were also at increased risk of preterm delivery (15.2% versus 7.8%, P =.002) and small-for-gestational-age infants (8.0% versus 3.1%, P =.001) compared with women without rheumatologic disease.

Conclusion: The finding that women with rheumatologic diseases are at increased risk of adverse obstetric outcomes suggests a need for heightened clinical vigilance and further research into the common pathophysiologic correlates.

Level of evidence: II-2

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / epidemiology*
  • Case-Control Studies
  • Databases, Factual
  • Female
  • Fetal Growth Retardation / epidemiology
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Logistic Models
  • Lupus Erythematosus, Systemic / epidemiology*
  • Obstetric Labor, Premature / epidemiology
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Risk Factors