The nature of human hazards associated with excessive intake of amino acids

J Nutr. 2004 Jun;134(6 Suppl):1633S-1639S; discussion 1664S-1666S, 1667S-1672S. doi: 10.1093/jn/134.6.1633S.


In recent years there has been a large increase in the consumption of individual amino acids as dietary supplements. This has resulted not only from the use of certain amino acids as flavoring agents, but other amino acids are taken for perceived health benefit, for enhancement of physical performance, as well as for psychological effects. Two reviews of the scientific literature exist that mainly deal with effects in animals, and three major reports consider the safety of amino acids for human consumption. This article is a brief summary of the available evidence regarding the safety of individual amino acids when taken in excess relative to the amounts absorbed from dietary protein.

Publication types

  • Review

MeSH terms

  • Amino Acids / administration & dosage*
  • Amino Acids / adverse effects*
  • Animals
  • Dose-Response Relationship, Drug
  • Humans


  • Amino Acids