Relationship between MMR vaccine and autism

Ann Pharmacother. 2004 Jul-Aug;38(7-8):1297-300. doi: 10.1345/aph.1D293. Epub 2004 Jun 1.


Objective: To evaluate the proposed link between the administration of the measles, mumps, and rubella (MMR) vaccine and the development of autism.

Data sources: A literature search utilizing MEDLINE (1966-November 2003), with the key terms measles, mumps, rubella, and autism, was conducted. Review of the references listed in the articles identified was also performed.

Data synthesis: Ten articles that specifically evaluated the possible relationship between the MMR vaccine and autism were identified. Review articles, commentaries, and evaluations of a link between gastrointestinal symptoms in autistic children and MMR immunization were excluded.

Conclusions: Based upon the current literature, it appears that there is no relationship between MMR vaccination and the development of autism.

Publication types

  • Review

MeSH terms

  • Autistic Disorder / etiology*
  • Child
  • Clinical Trials as Topic
  • Humans
  • Measles-Mumps-Rubella Vaccine / adverse effects*


  • Measles-Mumps-Rubella Vaccine