The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes

Eur J Clin Nutr. 2004 Nov;58(11):1553-6. doi: 10.1038/sj.ejcn.1602007.


Objective: Assessment of postprandial glycaemic response to four nutritional feeds with different macronutrient and fibre composition.

Design: A randomized, double-blind, crossover study.

Setting: University of Maastricht, the Netherlands.

Subjects: A total of 10 healthy volunteers and 10 patients with type II diabetes.

Interventions: Subjects received 200 kcal of four enteral nutrition products (two standard products and two diabetes-specific products). Fasting and postprandial plasma glucose were measured for 2 h. Peak glucose level and area under the curve were calculated.

Results: In healthy volunteers and diabetic patients, the feed with a low carbohydrate (CHO), high monounsaturated fatty acid (MUFA) and high fibre content significantly decreased peak glucose concentration and area under the curve compared to the feeds with standard composition.

Conclusions: Special feeds with a low CHO, high MUFA and high fibre content improve glycaemic balance and therefore should be considered in diabetic patients who are in need of nutritional support.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Area Under Curve
  • Blood Glucose / metabolism*
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / therapy
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Carbohydrates / metabolism
  • Dietary Fats, Unsaturated / administration & dosage*
  • Dietary Fats, Unsaturated / metabolism
  • Dietary Fiber / administration & dosage*
  • Dietary Fiber / metabolism
  • Double-Blind Method
  • Enteral Nutrition* / standards
  • Female
  • Glycemic Index
  • Humans
  • Male
  • Middle Aged
  • Postprandial Period


  • Blood Glucose
  • Dietary Carbohydrates
  • Dietary Fats, Unsaturated
  • Dietary Fiber