Progress on new vaccine strategies for the immunotherapy and prevention of cancer

J Clin Invest. 2004 Jun;113(11):1515-25. doi: 10.1172/JCI21926.


In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.

Publication types

  • Review

MeSH terms

  • Antigens, Neoplasm / immunology*
  • Cancer Vaccines / immunology
  • Cancer Vaccines / pharmacology*
  • Genetic Vectors
  • Humans
  • Immunotherapy
  • Neoplasms / immunology
  • Neoplasms / prevention & control*
  • Vaccines, DNA / immunology
  • Vaccines, DNA / pharmacology
  • Vaccines, Subunit / immunology
  • Viruses


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Vaccines, DNA
  • Vaccines, Subunit