The longest use of liposomal amphotericin B and 5-fluorocytosine in neonatal renal candidiasis

Pediatr Nephrol. 2004 Jul;19(7):801-4. doi: 10.1007/s00467-004-1463-7. Epub 2004 May 15.


Bilateral fungal obstruction of the renal collecting system is rare in infancy. Treatment options include medical or surgical procedures. Reports of successful medical treatment with liposomal amphotericin B have been published but the duration of treatment is controversial. We report a 3-week-old preterm baby with myelomeningocele who had experienced acute renal failure related to bilateral renal fungus balls, which improved with percutaneous nephrostomy and 12 weeks of liposomal amphotericin B intravenously combined with 5-fluorocytosine orally for 9 weeks.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / microbiology*
  • Amphotericin B / administration & dosage*
  • Antifungal Agents / administration & dosage*
  • Candidiasis / drug therapy*
  • Female
  • Flucytosine / administration & dosage*
  • Humans
  • Infant
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / microbiology*
  • Liposomes
  • Time Factors


  • Antifungal Agents
  • Liposomes
  • Amphotericin B
  • Flucytosine