Long-term results of bilateral pallidal stimulation in Parkinson's disease

Ann Neurol. 2004 Jun;55(6):871-5. doi: 10.1002/ana.20091.


We followed up 11 patients for up to 5 years after bilateral pallidal deep brain stimulation for advanced Parkinson's disease. Dyskinesias remained significantly reduced until the last assessment. The initial improvement of off-period motor symptoms and fluctuations, however, was not sustained and gradually declined. Beneficial effects of pallidal deep brain stimulation on activities of daily living in the on- and off-period were lost after the first year. Replacement of pallidal electrodes into the subthalamic nucleus in four patients could restore the initial benefit of deep brain stimulation and allowed a significant reduction of dopaminergic drug therapy.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Activities of Daily Living
  • Adult
  • Dyskinesias / physiopathology
  • Dyskinesias / therapy
  • Electric Stimulation / methods
  • Electric Stimulation Therapy* / methods
  • Female
  • Follow-Up Studies
  • Globus Pallidus / physiology
  • Globus Pallidus / radiation effects*
  • Globus Pallidus / surgery
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / therapy*
  • Prospective Studies
  • Severity of Illness Index
  • Subthalamic Nucleus / radiation effects
  • Subthalamic Nucleus / surgery
  • Time*
  • Treatment Outcome