The use of in-line intravenous filters in sick newborn infants

Acta Paediatr. 2004 May;93(5):658-62. doi: 10.1111/j.1651-2227.2004.tb02993.x.


Aim: This study assesses the improvement in outcome for newborn infants by decreasing major complications associated with intravenous fluid therapy by using an in-line filter, and evaluates the economical impact this might have in relation to daily changing of i.v. lines.

Methods: In a prospective controlled study, 88 infants were randomly assigned to receive either filtered (except for lipids, blood and blood products) or non-filtered infusions via a central catheter. Main outcome measures such as bacteraemia, phlebitis, extravasation, thrombosis, septicaemia and necrosis were all scored. The costs attributable to patients during a standard 8-day stay were also recorded.

Results: Significant reductions were found in major complications such as thrombi and clinical sepsis (control group (21), filter group (8); p < 0.05). Bacterial cultures of the filters showed a contamination rate on the upstream surface of 15/109 filters (14%). The mean costs of disposables were less in the filter group, showing a reduction from 31.17 euros to 23.79 euros.

Conclusions: The use of this in-line filter leads to a significant decrease in major complications and substantial cost savings.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catheterization, Central Venous*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infusions, Intravenous / instrumentation
  • Infusions, Intravenous / methods
  • Intensive Care Units, Neonatal / economics
  • Patient Care / economics
  • Pneumonia / complications
  • Pneumonia / therapy
  • Prospective Studies
  • Respiratory Distress Syndrome, Newborn / complications
  • Respiratory Distress Syndrome, Newborn / nursing
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Sepsis / complications
  • Sepsis / therapy