Mammary myofibroblastoma: report of two cases with fine-needle aspiration cytology and review of the cytology literature

Diagn Cytopathol. 2004 Jun;30(6):406-10. doi: 10.1002/dc.20042.


Fine-needle aspirates from two histologically, immunohistochemically, and ultrastructurally confirmed mammary myofibroblastomas (MM) of two elderly women revealed abundant, randomly arranged single and clustered benign spindle-shaped mesenchymal cells with scant cytoplasm and elongated or oval nuclei displaying a finely granular chromatin pattern and inconspicuous nucleoli. In one case a few cells showed inconspicuous nuclear grooves. The aspirated tumor cells from the other case stained positively with desmin and CD34 antibodies and negatively with cytokeratin and S-100 protein antibodies, in keeping with an MM. A review of the literature was briefly presented.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, CD34 / analysis
  • Biopsy, Fine-Needle
  • Breast Neoplasms / pathology*
  • Cytodiagnosis
  • Desmin / analysis
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Neoplasms, Muscle Tissue / pathology*
  • S100 Proteins / analysis


  • Antigens, CD34
  • Desmin
  • Neoplasm Proteins
  • S100 Proteins