Pulsatile luteinizing hormone disruption in depression

Psychoneuroendocrinology. 2004 Aug;29(7):825-9. doi: 10.1016/S0306-4530(03)00146-X.


Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Data Interpretation, Statistical
  • Depressive Disorder / blood*
  • Female
  • Follicular Phase / blood*
  • Fourier Analysis
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology*
  • Luteal Phase / blood*
  • Luteinizing Hormone / blood*
  • Middle Aged
  • Models, Biological*
  • Periodicity


  • Luteinizing Hormone