Molecular characterization of a virulent canine coronavirus BGF strain

Virus Res. 2004 Aug;104(1):27-31. doi: 10.1016/j.virusres.2004.02.038.


Molecular characterisation of a canine coronavirus (CCoV) isolate (BGF), associated with an outbreak of diarrhoea in puppies, showed 92.7% identity with attenuated Insavc-1 strain. Canine coronavirus BGF revealed a full length non-structural protein 3b (nsp 3b), associated with virulence in other coronaviruses, and a highly divergent region at the amino terminal domain of the membrane protein that may be implicated in avoiding the host immune reaction. This new canine coronavirus strain could help to identify virulence factors in coronavirus.

MeSH terms

  • Animals
  • Coronavirus Infections / veterinary*
  • Coronavirus Infections / virology
  • Coronavirus, Canine / classification*
  • Coronavirus, Canine / genetics*
  • Coronavirus, Feline / genetics
  • Diarrhea / veterinary
  • Diarrhea / virology
  • Dogs
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Viral Envelope Proteins / biosynthesis
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / genetics


  • Membrane Glycoproteins
  • Viral Envelope Proteins

Associated data

  • GENBANK/AY342160