Abstract
In reviewing my lifework, I wish to summarize the results of studies on the development of new biological-active compounds. The following subjects are discussed: 1) syntheses and biological activities of benzoxazole derivatives, 2) structure-activity relationships of phyllodulcin, a natural sweetner, and 3,4-dihydroisocoumarins for sweetness, 3) syntheses and structure-activity relationships of spiro[isocoumarin-piperidine] analogs for antiallergic activity, 4) design, structure-activity relationships, and a mechanism of antitumor action of bistropolone derivatives, 5) design, structure-activity relationships of fused tetracyclic quinolines for antitumor activity.
MeSH terms
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Analgesics
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Animals
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / pharmacology
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Benzopyrans* / chemical synthesis
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Benzopyrans* / pharmacology
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Benzoxazoles* / chemical synthesis
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Benzoxazoles* / pharmacology
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DNA, Neoplasm / biosynthesis
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Drug Design
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Humans
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Isocoumarins
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Monoterpenes*
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Quinolines / chemical synthesis
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Quinolines / pharmacology
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Structure-Activity Relationship
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Sweetening Agents
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Tropolone / analogs & derivatives
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Tropolone / chemical synthesis
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Tropolone / pharmacology
Substances
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Analgesics
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Antineoplastic Agents
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Benzopyrans
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Benzoxazoles
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DNA, Neoplasm
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Isocoumarins
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Monoterpenes
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Quinolines
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Sweetening Agents
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agrimonolide
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6-methoxybenzoxazolinone
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Tropolone
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beta-thujaplicin