[Activity of the messenger systems in the altitude chamber hypoxia]

Biomed Khim. 2004 Mar-Apr;50(2):187-91.
[Article in Russian]

Abstract

The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) caused further impairments in the second messenger content. The synergism between phosphoinositide and adenylatcyclase systems was demonstrated.

MeSH terms

  • Adenylyl Cyclase Inhibitors
  • Adenylyl Cyclases / metabolism*
  • Adrenergic beta-Antagonists / pharmacology
  • Altitude
  • Animals
  • Brain / enzymology
  • Brain / metabolism
  • Hypoxia / enzymology
  • Hypoxia / metabolism*
  • Lithium / pharmacology
  • Phosphatidylinositols / antagonists & inhibitors
  • Phosphatidylinositols / metabolism*
  • Propranolol / pharmacology
  • Rats
  • Second Messenger Systems / physiology*

Substances

  • Adenylyl Cyclase Inhibitors
  • Adrenergic beta-Antagonists
  • Phosphatidylinositols
  • Lithium
  • Propranolol
  • Adenylyl Cyclases