[Levels of unified metabolites and thyroid hormones in blood and oral fluid of children with minimal brain dysfunction]

Biomed Khim. 2004 Mar-Apr;50(2):204-10.
[Article in Russian]


Minimal brain dysfunctions in children with various perinatal complications are accompanied by metabolic imbalance manifested by decreased total protein content, the tendency to reduced triglycerides, increased cholesterol concentrations in the oral fluid, the trend to hypoproteinaemia, hypoglycaemia, hypotriglyceridaemia. The most significant changes in the redox systems alpha-ketoglutarate-glutamate, oxaloacetate-malate, pyruvate-lactate, dioxyacetone phosphate-alpha-glycerophosphate in biological fluids were revealed in cases of antenatal alcoholisation. A certain correlation was found between anemia in pregnant women and hypothyroidal background in children. In addition, a high level of free and total thyroxine, that of total triiodthyronine were found in the oral fluid. Hypophysis--thyroid dysregulation in children with minimal brain dysfunction associated with gestosis in their mothers during pregnancy, was manifested by decreased content of total and free T4 and T3 in blood serum and increased level of the thyroid-stimulating hormone.

Publication types

  • English Abstract

MeSH terms

  • Attention Deficit Disorder with Hyperactivity / blood
  • Attention Deficit Disorder with Hyperactivity / metabolism*
  • Carboxylic Acids / analysis
  • Carboxylic Acids / blood
  • Child
  • Child, Preschool
  • Female
  • Glucose / analysis
  • Humans
  • Lipids / analysis
  • Lipids / blood
  • Oxidation-Reduction
  • Pregnancy
  • Pregnancy Complications
  • Proteins / analysis
  • Saliva / chemistry*
  • Saliva / metabolism*
  • Thyroid Hormones / analysis*
  • Thyroid Hormones / blood


  • Carboxylic Acids
  • Lipids
  • Proteins
  • Thyroid Hormones
  • Glucose