Herb-drug interactions: an evidence based approach

Curr Med Chem. 2004 Jun;11(11):1513-25. doi: 10.2174/0929867043365198.

Abstract

The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidence-based appraisal of the current literature is essential to guide practitioners involved in patient care.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evidence-Based Medicine / methods*
  • Herb-Drug Interactions*
  • Herbal Medicine / classification
  • Humans
  • Plant Preparations / administration & dosage
  • Plant Preparations / pharmacology*
  • Randomized Controlled Trials as Topic

Substances

  • Plant Preparations