Steroid treatment for relapses in multiple sclerosis - the evidence urges shared decision-making

Acta Neurol Scand. 2004 Jul;110(1):1-5. doi: 10.1111/j.1600-0404.2004.00284.x.

Abstract

Objectives: Therapy of acute relapses in multiple sclerosis with corticosteroids (CC) remains uncertain with respect to route, dosage and effectiveness. This makes the treatment of relapses a clinical field where 'shared decision-making (SDM)' could be of advantage for the patients. A prerequisite for SDM is the provision of evidence-based information for the patients. The British General Medical Council (GMC) has published ethical guidelines on seeking patients' consent for medical interventions, formulating topics of information patients need in order to make an informed treatment decision.

Methods: Medical databases were searched for evidence on the treatment of acute relapses with CC.

Results: The available evidence on relapse treatment is ambiguous and weak. It does not provide enough evidence to sufficiently inform patients following the topics formulated by the GMC.

Conclusion: Good evidence is lacking, supporting the concept of SDM in the therapy of relapses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenal Cortex Hormones / adverse effects
  • Dose-Response Relationship, Drug
  • Humans
  • Informed Consent / ethics
  • Informed Consent / standards*
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Multiple Sclerosis, Relapsing-Remitting / physiopathology
  • Multiple Sclerosis, Relapsing-Remitting / prevention & control*
  • Patient Education as Topic / standards
  • Patient Participation*
  • Practice Guidelines as Topic*
  • Risk
  • Secondary Prevention
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones