Therapeutic benefits from targeting of ADAM family members

Biochemistry. 2004 Jun 15;43(23):7227-35. doi: 10.1021/bi049677f.

Abstract

Members of the ADAM (a disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of many single transmembrane-bound proteins ranging from cell surface receptors to growth factors and cytokines. Because of the biological significance of these processing events, a recurring theme in studying ADAM biology is that they are involved in physiological processes that can go awry and lead to disease states. This review provides a comprehensive look at ADAM family members and their role in pathology and provides a pathway for determining whether an enzyme is a physiological convertase for a given protein. In addition, ADAMs are discussed as potential therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disintegrins / metabolism*
  • Drug Design*
  • Growth Substances / metabolism
  • Humans
  • Inflammation / metabolism
  • Inflammation / therapy
  • Membrane Proteins / metabolism
  • Metalloproteases / metabolism*

Substances

  • Disintegrins
  • Growth Substances
  • Membrane Proteins
  • Metalloproteases