Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissus sicyoides

BMC Pharmacol. 2004 Jun 8:4:9. doi: 10.1186/1471-2210-4-9.

Abstract

Background: Cissus sicyoides (Vitaceae) is a medicinal plant popularly known in Brazil as "cipó-pucá, anil-trepador, cortina, and insulina". The plant is used in several diseases, including rheumatism, epilepsy, stroke and also in the treatment of diabetes. In the present work, we studied the hypoglycemic and anti-lipemic effects of the aqueous extract prepared from fresh leaves of the plant (AECS), in the model of alloxan-induced diabetes in rats. In addition, hepatic enzyme levels were also determined.

Results: Results showed that the daily treatment of diabetic rats with AECS for 7 days (100 and 200 mg/kg, p.o.) significantly decreased blood glucose levels in 25 and 22% respectively, as compared to the same groups before AECS treatment. No significant changes were seen in control diabetic rats before (48 h after alloxan administration) and after distilled water treatment. While no changes were seen in total cholesterol levels, a significant decrease was observed in plasma triglyceride levels, in the alloxan-induced diabetic rats after AECS treatment with both doses, as compared to the same groups before treatment. Significant decreases in blood glucose (25%) and triglyceride levels (48%) were also observed in the alloxan-induced diabetic rats after 4 days treatment with AECS (200 mg/kg, p.o.). Aspartate (AST) and alanine (ALT) aminotransferases levels, in diabetic controls and AECS-treated rats, were in the range of reference values presented by normal rats.

Conclusions: The results justify the popular use of C. sicyoides, pointing out to the potential benefit of the plant aqueous extract (AECS) in alternative medicine, in the treatment of type 2 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloxan / adverse effects
  • Animals
  • Cissus / chemistry*
  • Diabetes Mellitus, Experimental / blood
  • Hypoglycemic Agents / pharmacology*
  • Lipids / blood*
  • Male
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry
  • Rats
  • Rats, Wistar

Substances

  • Hypoglycemic Agents
  • Lipids
  • Plant Extracts
  • Alloxan