Wnt signaling: Ig-norrin the dogma

Curr Biol. 2004 Jun 8;14(11):R436-7. doi: 10.1016/j.cub.2004.05.039.

Abstract

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

Publication types

  • Review

MeSH terms

  • Blindness / genetics*
  • Extracellular Matrix / metabolism
  • Frizzled Receptors
  • Humans
  • LDL-Receptor Related Proteins
  • Ligands
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Mutation / genetics
  • Proteins / metabolism*
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, LDL / metabolism
  • Signal Transduction*

Substances

  • FZD4 protein, human
  • Frizzled Receptors
  • LDL-Receptor Related Proteins
  • LRP5 protein, human
  • LRP6 protein, human
  • Ligands
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Proteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, LDL