An overview of the KIN1/PAR-1/MARK kinase family

Biol Cell. 2004 Apr;96(3):193-9. doi: 10.1016/j.biolcel.2003.10.009.


Members of the KIN1/PAR-1/MARK kinase family are conserved from yeast to humans and share a similar primary structural organization. Several kinases of this family appear to be at the crossroads of various biological functions including cell polarity, cell cycle control, intracellular signalisation, microtubules stability and protein stability. Here we present an overview of known roles of KIN1/PAR-1/MARK kinases including pEg3 a newly identified member which is regulated during the cell cycle and is a potential regulator of the cell cycle progression. Some common modes of action can be deciphered for this protein kinase family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Division / physiology
  • Humans
  • Phosphoproteins / physiology
  • Protein Kinases / physiology
  • Protein-Serine-Threonine Kinases / classification*
  • Protein-Serine-Threonine Kinases / physiology*
  • Saccharomyces cerevisiae Proteins / physiology
  • Signal Transduction / physiology
  • Xenopus Proteins / physiology
  • Yeasts


  • Phosphoproteins
  • Saccharomyces cerevisiae Proteins
  • Xenopus Proteins
  • Protein Kinases
  • pEg3 protein, Xenopus
  • KIN1 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases