The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons

Front Neuroendocrinol. 2004 Apr;25(1):1-26. doi: 10.1016/j.yfrne.2004.03.001.

Abstract

This review summarizes the mechanisms of neurotoxicity associated to androgen receptor containing an elongated polyglutamine tract responsible for motor neuronal cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Stem / cytology
  • Brain Stem / metabolism*
  • Cell Death / physiology
  • Humans
  • Male
  • Motor Neurons / chemistry
  • Motor Neurons / metabolism*
  • Muscular Disorders, Atrophic / metabolism*
  • Mutation
  • Neurotoxins / genetics
  • Neurotoxins / metabolism
  • Peptides / genetics
  • Peptides / metabolism*
  • Receptors, Androgen / genetics
  • Receptors, Androgen / metabolism*
  • Spinal Cord / cytology
  • Spinal Cord / metabolism*

Substances

  • Neurotoxins
  • Peptides
  • Receptors, Androgen
  • polyglutamine

Grant support