Molecular genetics of age-related cataract

Exp Eye Res. 2004 Jul;79(1):3-9. doi: 10.1016/j.exer.2004.03.014.


Advances in molecular biological and genetic technology have greatly accelerated elucidation of the genetic contribution to age-related cataract. Epidemiological studies have documented tendencies for cataracts to occur more frequently in relatives of cataract patients than in the general population, genetic studies have demonstrated contributory roles of some specific genes in age related cataract in small populations, and molecular studies have shown changes in expression of specific genes in cataractous lenses. Together, these studies are beginning to provide a conceptual framework for understanding age-related cataracts.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Aging / physiology*
  • Animals
  • Cataract / genetics*
  • Cataract / metabolism
  • Crystallins / genetics*
  • Crystallins / metabolism
  • Gene Expression
  • Humans
  • Lens, Crystalline / metabolism*
  • Mice
  • Models, Animal
  • Mutation
  • Oxidative Stress


  • Crystallins