The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells

Gene Expr Patterns. 2004 Jul;4(4):389-95. doi: 10.1016/j.modgep.2004.01.008.

Abstract

The proliferation associated nuclear element (PANE1) had been identified in a screen for genes activated in mouse mammary epithelium transformed by stabilized beta-catenin. We have now cloned the human and zebrafish orthologs, analyzed their expression and expressed them ectopically in tissue culture cell lines. PANE1 consists of 180 amino acids and displays 38% conservation between man and zebrafish. Expression of the human PANE1 gene was detected preferentially in immune cells including leukemias and lymphomas, tumor tissues and tumor derived cell lines. In B- and T-cells PANE1 RNA was only detected after the respective cell types were activated either in vivo or in vitro.

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism*
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Humans
  • Lymphocyte Activation / genetics
  • Lymphocyte Activation / physiology*
  • Mice
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Nuclear Proteins / biosynthesis
  • Nuclear Proteins / genetics*
  • Sequence Homology, Amino Acid
  • T-Lymphocytes / metabolism*
  • Zebrafish / genetics
  • Zebrafish Proteins / genetics*

Substances

  • Cell Cycle Proteins
  • Nuclear Proteins
  • PANE1 protein, zebrafish
  • Zebrafish Proteins
  • proliferation associated nuclear element 1 protein, mouse
  • proliferation associated nuclear element protein 1, human