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Review
. 2004;5(6):226.
doi: 10.1186/gb-2004-5-6-226. Epub 2004 May 28.

An overview of the basic helix-loop-helix proteins

Susan Jones  1
Affiliations
Review

An overview of the basic helix-loop-helix proteins

Susan Jones. Genome Biol. 2004.

Abstract

The basic helix-loop-helix proteins are dimeric transcription factors that are found in almost all eukaryotes. In animals, they are important regulators of embryonic development, particularly in neurogenesis, myogenesis, heart development and hematopoiesis.

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Figures

Figure 1
Figure 1
Representative structures of bHLH proteins from the Protein Data Bank [22]. In each diagram, the protein is shown as a secondary-structure cartoon and the DNA double helix is shown in stick representation. (a) MyoD bHLH-domain homodimer (PDB code 1mdy). (b) Pho4 bHLH-domain homodimer (1am9). (c) SREBP-1a bHLH-domain homodimer (1aoaC). (d) Max-Mad heterodimer (1nlw). (e) Max-Myc heterodimer (1nkp). (f) Max-Myc heterotetramer (1nkp). In (d-f) the Max HLH monomer is shown in dark gray. The scales are not comparable between different structures.
See this image and copyright information in PMC

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References

    1. Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol. 2000;20:429–440. doi: 10.1128/MCB.20.2.429-440.2000. - DOI - PMC - PubMed
    1. Ledent V, Vervoort M. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Genome Res. 2001;11:754–770. doi: 10.1101/gr.177001. - DOI - PMC - PubMed
    1. Robinson KA, Lopes JM. Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes. Nucleic Acids Res. 2000;28:1499–1505. doi: 10.1093/nar/28.7.1499. - DOI - PMC - PubMed
    1. Moore AW, Barbel S, Jan LY, Jan YN. A genomewide survey of basic helix-loop-helix factors in Drosophila. Proc Natl Acad Sci USA. 2000;97:10436–10441. doi: 10.1073/pnas.170301897. - DOI - PMC - PubMed
    1. Peyrefitte S, Kahn D, Haenlin M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Mech Dev. 2001;104:99–104. doi: 10.1016/S0925-4773(01)00360-4. - DOI - PubMed

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