LKB1 kinase: master and commander of metabolism and polarity

Curr Biol. 2004 May 25;14(10):R383-5. doi: 10.1016/j.cub.2004.05.012.


LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport / metabolism
  • Cell Polarity / physiology*
  • Humans
  • Peutz-Jeghers Syndrome / genetics
  • Peutz-Jeghers Syndrome / physiopathology*
  • Phosphotransferases (Phosphate Group Acceptor) / metabolism*
  • Protein Synthesis Inhibitors / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*


  • Adaptor Proteins, Vesicular Transport
  • Protein Synthesis Inhibitors
  • STRAD protein, human
  • STK11 protein, human
  • Protein-Serine-Threonine Kinases
  • AMP-dependent kinase (ATP-forming)
  • Phosphotransferases (Phosphate Group Acceptor)