Translesion DNA synthesis: little fingers teach tolerance

Curr Biol. 2004 May 25;14(10):R389-91. doi: 10.1016/j.cub.2004.05.014.


DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.

Publication types

  • Review

MeSH terms

  • Base Sequence / genetics
  • DNA Damage*
  • DNA Replication / genetics
  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / metabolism*
  • Models, Molecular*
  • Mutation / genetics
  • Protein Conformation


  • DNA-Directed DNA Polymerase