Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders

Cell. 2004 Jun 11;117(6):693-7. doi: 10.1016/j.cell.2004.05.019.


The recent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia and flagella has triggered a renaissance of interest in these organelles that transcends studies on their well-characterized ability to move. New studies on several fronts have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction, and that mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity, hypertension, and diabetes.

Publication types

  • Review

MeSH terms

  • Animals
  • Bardet-Biedl Syndrome / genetics
  • Bardet-Biedl Syndrome / metabolism
  • Bardet-Biedl Syndrome / physiopathology
  • Cell Differentiation / physiology*
  • Chlamydomonas / growth & development
  • Chlamydomonas / metabolism
  • Chlamydomonas / ultrastructure
  • Cilia / genetics
  • Cilia / metabolism*
  • Ciliary Motility Disorders / metabolism
  • Ciliary Motility Disorders / physiopathology
  • Flagella / genetics
  • Flagella / metabolism*
  • Humans
  • Polycystic Kidney Diseases / genetics
  • Polycystic Kidney Diseases / metabolism
  • Protein Transport / physiology
  • Signal Transduction / physiology