Protein tyrosine phosphatases in the human genome

Cell. 2004 Jun 11;117(6):699-711. doi: 10.1016/j.cell.2004.05.018.


Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence / genetics
  • Gene Expression Regulation, Enzymologic / genetics*
  • Genome, Human*
  • Humans
  • Phosphorylation
  • Phylogeny
  • Protein Structure, Tertiary / genetics
  • Protein Tyrosine Phosphatases / classification
  • Protein Tyrosine Phosphatases / genetics*
  • Protein Tyrosine Phosphatases / metabolism*
  • Signal Transduction / genetics*
  • Tyrosine / metabolism*


  • Tyrosine
  • Protein Tyrosine Phosphatases