Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers

Biol Pharm Bull. 2004 Jun;27(6):802-5. doi: 10.1248/bpb.27.802.


Forty hyperlipidemic patients, smokers and non-smokers, were studied. Subjects received 15 g young barley leaf extract (BL) or 60 g adlay daily for four weeks. Overnight fasting blood samples were drawn immediately prior to and after four weeks of supplementation. Blood samples were analyzed for plasma lipid profiles and their susceptibility to low-density lipoprotein (LDL) oxidation. The plasma total and LDL-cholesterol (LDL-C) levels were reduced following treatment with either BL or adlay; furthermore, the lag phase of LDL oxidation increased after either supplementation. However, it seemed that BL had stronger antioxidative effect on the prevention of LDL oxidation than adlay. Our results also indicated that the antioxidative effect was less pronounced in smokers than in non-smokers. Therefore, supplementation with BL or adlay can decrease plasma lipids and inhibit LDL oxidation in hyperlipidemic smokers and/or non-smokers.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Coix*
  • Hordeum*
  • Humans
  • Hyperlipidemias / blood*
  • Hyperlipidemias / drug therapy
  • Lipids / blood*
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Oxidation-Reduction / drug effects
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Smoking / blood*
  • Smoking / drug therapy


  • Lipids
  • Lipoproteins, LDL
  • Plant Extracts