Single DNA rotaxanes of a transmembrane pore protein

Angew Chem Int Ed Engl. 2004 Jun 7;43(23):3063-7. doi: 10.1002/anie.200453907.


Supramolecular chemistry at the single-molecule level. An α-hemolysin transmembrane pore can be threaded in a desired orientation by DNA-PEG hybrid strands to yield functional rotaxanes. The single-molecule rotaxanes display stable and reversible two-state switching capacity depending on the applied potential, orientation, and the method of threading and capture used.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Cell Membrane / chemistry
  • DNA, Single-Stranded / chemistry*
  • DNA, Single-Stranded / metabolism
  • Hemolysin Proteins / chemistry*
  • Hemolysin Proteins / metabolism
  • Membrane Transport Proteins / chemistry*
  • Molecular Sequence Data
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / metabolism
  • Rotaxanes / chemistry*
  • Rotaxanes / metabolism


  • DNA, Single-Stranded
  • Hemolysin Proteins
  • Membrane Transport Proteins
  • Rotaxanes
  • Polyethylene Glycols