Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers

J Med Chem. 2004 Jun 17;47(13):3329-33. doi: 10.1021/jm034224e.


Recent studies have indicated that the most important role of beta-amyloid peptide (Abeta) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Abeta(1-42) neurotoxic intermediates (called ADDLs). In the present work we describe the preparation of per-6-amino-6-deoxy-beta-cyclodextrins, which inhibit ADDLs formation in vitro.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / chemistry*
  • Cyclodextrins / chemical synthesis*
  • Cyclodextrins / chemistry
  • Oligopeptides / chemistry*
  • Peptide Fragments / chemistry*
  • Solubility
  • Structure-Activity Relationship


  • Amyloid beta-Peptides
  • Cyclodextrins
  • Oligopeptides
  • Peptide Fragments
  • amyloid beta-protein (1-42)