The molecular mechanics of eukaryotic translation

Annu Rev Biochem. 2004;73:657-704. doi: 10.1146/annurev.biochem.73.030403.080419.


Great advances have been made in the past three decades in understanding the molecular mechanics underlying protein synthesis in bacteria, but our understanding of the corresponding events in eukaryotic organisms is only beginning to catch up. In this review we describe the current state of our knowledge and ignorance of the molecular mechanics underlying eukaryotic translation. We discuss the mechanisms conserved across the three kingdoms of life as well as the important divergences that have taken place in the pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Archaeal Proteins / biosynthesis
  • Archaeal Proteins / genetics
  • Codon, Initiator
  • Eukaryotic Cells
  • Eukaryotic Initiation Factors / metabolism
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / genetics
  • Models, Biological
  • Peptide Chain Initiation, Translational
  • Peptide Chain Termination, Translational
  • Protein Biosynthesis*
  • Proteins / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism


  • Archaeal Proteins
  • Codon, Initiator
  • Eukaryotic Initiation Factors
  • Fungal Proteins
  • Proteins
  • RNA, Messenger