Cystic fibrosis presenting as new onset diabetes mellitus in adolescent twins

Pediatr Diabetes. 2004 Jun;5(2):99-101. doi: 10.1111/j.1399-543X.2004.00033.x.


We describe identical adolescent twin girls who presented with symptoms consistent with type 1 diabetes. Medical work up for evaluation of gastrointestinal symptoms led to a diagnosis of cystic fibrosis (CF) in both. These cases suggest that diabetes can be a presenting symptom of CF in the absence of pulmonary symptomatology.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Alleles
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / diagnosis*
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diagnosis, Differential
  • Diseases in Twins / diagnosis*
  • Female
  • Humans
  • Twins, Monozygotic


  • CFTR protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator