[Study on T cell subsets and their activated molecules from the convalescent SARS patients during two follow-up surveys]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 May;20(3):322-4.
[Article in Chinese]


Aim: To explore the changes of peripheral blood T cell subsets and their activated molecules in convalescent SARS patients.

Methods: In two follow-up surveys of the SARS patients discharged from our hospital, the changes of CD3(+), CD4(+), CD8(+), CD8(+) CD28(+), CD8(+) CD28(-), CD3(+) CD25(+), CD3(+) CD69(+), CD3(+) HLA-DR(+)T cells and the ratio of CD4(+)/CD8(+) T cells in peripheral blood of SARS patients treated unitedly with Chinese and Western medicines were detected by flow cytometry.

Results: In two follow-up surveys, the percentages of CD3(+), CD4(+), CD8(+) CD28(+) T cells and the ratio of CD4(+)/CD8(+) T cells were remarkably lower than those of normal values(P<0.05), while the percentage of CD8(+) CD28 (-) T cells was higher(P<0.01). As for the percentages of CD3(+), CD8(+), CD4(+)/CD8(+), CD3(+) CD25(+), CD3(+) CD69(+) and CD3(+) HLA-DR(+) T cells, there was marked difference between 1st and 2nd follow-up results, but for other molecules there was no notable difference.

Conclusion: The convalescent SARS patients' immune function gradually recovers, and the effect of SARS virus on activation of T cells gradually disappears.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD3 Complex / metabolism
  • CD4 Antigens / metabolism
  • CD4-CD8 Ratio
  • CD8 Antigens / metabolism
  • Convalescence*
  • Flow Cytometry
  • Follow-Up Studies
  • Humans
  • Lymphocyte Count
  • Severe Acute Respiratory Syndrome / immunology*
  • T-Lymphocyte Subsets / immunology*


  • CD3 Complex
  • CD4 Antigens
  • CD8 Antigens