Development of a 4-D digital mouse phantom for molecular imaging research

Mol Imaging Biol. 2004 May-Jun;6(3):149-59. doi: 10.1016/j.mibio.2004.03.002.


Purpose: We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research.

Methods: Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained from normal mice. Pilot simulation studies in single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) were performed to demonstrate the utility of the phantom.

Results: NURBS are an efficient and flexible way to accurately model the anatomy and cardiac and respiratory motions for a realistic 4-D digital mouse phantom. The phantom is capable of producing realistic molecular imaging data from which imaging devices and techniques can be evaluated.

Conclusion: The phantom provides a unique and useful tool in molecular imaging research. It can be used in the development of new imaging instrumentation, image acquisition strategies, and image processing and reconstruction methods.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Image Processing, Computer-Assisted / instrumentation
  • Mice / anatomy & histology*
  • Mice / physiology
  • Models, Anatomic*
  • Models, Animal*
  • Phantoms, Imaging*
  • Tomography, Emission-Computed, Single-Photon / instrumentation*
  • Tomography, X-Ray Computed / instrumentation*