Myocardial viability in patients with ischemic cardiomyopathy-evaluation by 3-D integration of myocardial scintigraphic data--and coronary angiographic data

Mol Imaging Biol. 2004 May-Jun;6(3):160-71. doi: 10.1016/j.mibio.2004.02.002.

Abstract

Purpose: To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory.

Procedures: In 105 patients, the combination of perfusion and metabolic imaging with (201)thallium ((201)TI) single-photon emission computed tomography (SPECT) and 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET) determined viability in dysfunctional myocardium. In addition, the value of 3-D scintigraphic fusion imaging was assessed in these patients.

Results: Based on the presence of viable dysfunctional myocardium, 54% of patients with ischemic cardiomyopathy may be considered for coronary revascularization. In 31 of 105 patients, the 3-D fusion imaging was estimated to be helpful in the diagnostic and interpretative process.

Conclusion: In patients with end-stage coronary artery disease scintigraphic imaging is most important in the decision-making process. Three-dimensional fusion imaging may add important information in approximately 30% of these patients.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Cardiomyopathies / diagnostic imaging*
  • Coronary Angiography / methods*
  • Female
  • Fluorodeoxyglucose F18
  • Heart / diagnostic imaging
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Middle Aged
  • Myocardial Ischemia / diagnostic imaging*
  • Myocardium / cytology
  • Prognosis
  • Thallium
  • Tomography, Emission-Computed / methods*

Substances

  • Fluorodeoxyglucose F18
  • thallium chloride
  • Thallium