Can oral cholera vaccination play a role in controlling a cholera outbreak?

Vaccine. 2004 Jun 23;22(19):2444-51. doi: 10.1016/j.vaccine.2003.11.070.


Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% CI: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Cholera / epidemiology*
  • Cholera / immunology
  • Cholera / prevention & control*
  • Cholera / transmission
  • Cholera Vaccines / administration & dosage*
  • Cholera Vaccines / immunology
  • Disease Outbreaks / economics
  • Disease Outbreaks / prevention & control*
  • Humans
  • Vaccination


  • Cholera Vaccines