The association of fasting glucose levels with congestive heart failure in diabetic adults > or =65 years: the Cardiovascular Health Study

J Am Coll Cardiol. 2004 Jun 16;43(12):2236-41. doi: 10.1016/j.jacc.2003.10.074.


Objectives: The purpose of this study was to determine if fasting glucose levels are an independent risk factor for congestive heart failure (CHF) in elderly individuals with diabetes mellitus (DM) with or without coronary heart disease (CHD).

Background: Diabetes mellitus and CHF frequently coexist in the elderly. It is not clear whether fasting glucose levels in the setting of DM are a risk factor for incident CHF in the elderly.

Methods: A cohort of 829 diabetic participants, age > or =65 years, without prevalent CHF, was followed for five to eight years. The Cox proportional hazards modeling was used to determine the risk of CHF by fasting glucose levels. The cohort was categorized by the presence or absence of prevalent CHD.

Results: For a 1 standard deviation (60.6 mg/dl) increase in fasting glucose, the adjusted hazard ratios for incident CHF among participants without CHD at baseline, with or without an incident myocardial infarction (MI) or CHD event on follow-up, was 1.41 (95% confidence interval 1.24 to 1.61; p < 0.0001). Among those with prevalent CHD at baseline, with or without another incident MI or CHD event on follow-up, the corresponding adjusted hazard ratio was 1.27 (95% confidence interval 1.02 to 1.58; p < 0.05).

Conclusions: Among older adults with DM, elevated fasting glucose levels are a risk factor for incident CHF. The relationship of fasting glucose to CHF differs somewhat by the presence or absence of prevalent CHD.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Blood Pressure / physiology
  • Coronary Disease / epidemiology
  • Coronary Disease / metabolism
  • Coronary Disease / physiopathology
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus / physiopathology
  • Diabetic Angiopathies / epidemiology
  • Diabetic Angiopathies / metabolism*
  • Diabetic Angiopathies / physiopathology
  • Fasting / metabolism*
  • Female
  • Follow-Up Studies
  • Heart Failure / epidemiology
  • Heart Failure / metabolism*
  • Heart Failure / physiopathology
  • Humans
  • Incidence
  • Male
  • Proportional Hazards Models
  • Risk Factors
  • Statistics as Topic
  • Stroke Volume / physiology
  • Ventricular Function, Left / physiology


  • Biomarkers
  • Blood Glucose