Rho GTPases and activity-dependent dendrite development

Curr Opin Neurobiol. 2004 Jun;14(3):297-304. doi: 10.1016/j.conb.2004.05.012.


Dendritic morphology has an important influence on neuronal information processing. Multiple environmental cues, including neuronal activity, the neurotrophin family of growth factors, and extracellular guidance molecules have been shown to influence dendritic size, shape, and development. The Rho GTPases have emerged as key integrators of these environmental cues to regulate the underlying dendritic cytoskeleton.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Cell Differentiation / physiology*
  • Central Nervous System / cytology
  • Central Nervous System / growth & development*
  • Dendrites / enzymology*
  • Dendrites / ultrastructure
  • Extracellular Matrix / metabolism
  • Humans
  • Nerve Growth Factors / metabolism
  • Signal Transduction / physiology
  • Synaptic Transmission / physiology
  • rho GTP-Binding Proteins / metabolism*


  • Nerve Growth Factors
  • rho GTP-Binding Proteins