Association of G72/G30 with schizophrenia in the Chinese population

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1281-6. doi: 10.1016/j.bbrc.2004.05.119.


Recently, the G72 gene was reported to be associated with schizophrenia in the French Canadian and Russian populations. Here, we report the results obtained from the study of six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs1935062, rs778293, and rs3918342), which span an 82-kb region covering the complementary DNA sequences of G72 and G30, in 537 schizophrenia cases and 538 controls of the Han Chinese. In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia. Our data provide further evidence that markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Carrier Proteins / genetics*
  • China
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Proteins / genetics*
  • RNA, Messenger
  • Schizophrenia / genetics*


  • Carrier Proteins
  • DAOA protein, human
  • DAOAAS gene product, human
  • Genetic Markers
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • RNA, Messenger